Sheffield Type 2 Diabetes Treatment Model version 3: with the Embedding RCT health economic analyses implemented

This folder contains the economic model used to analyse the economic consequences of the Embedding RCT. The Embedding package was designed to increase the uptake of structured self management education for people with type 2 diabetes. The model is in R software, it requires the use of the doParrallel and dplyr packages, which can be downloaded from CRAN within R. The analysis was originally conducted in R version 4.4.1.The economic model is a mathematical simulation of the consequences of diabetes, with these driving estimates of costs and benefits over a life time. All simulated data that are input into the model for analysis are in the DATA folder. The individual level data on baseline characteristics or used to generate the estimates of how well Embedding is likely to work are not provided in this software and have data sharing methods (see the referenced papers for more details). The R script that runs the analyses in this project, is the Run All Analyses.R file.

This software relates to the following papers:

The original version: Davies MJ, Agarwal S, Bodicoat D, Brennan A, Dixon S, Eborall H, Glab A, Gray LJ, Hadjiconstantinou M, Huddlestone L, Hudson N, Keetharuth A, Khunti K, Kristunas C, Martin G, Northern A, Patterson M, Pollard D, Pritchard R, Schreder S, Speight J, Stribling B, Sturt J, Turner J, Weis C. Increasing uptake of self-management education programmes for type 2 diabetes in primary care: the Embedding research programme including an RCT. Programme Grants for Applied Research. In Press.

The original version does lack some features (e.g. detailed technical document, some scenario analyses by the reviewers of the paper) that were developed between this analysis been submitted and the subsequent

The final version: Pollard D, Keetharuth A, Brennan A, Bodicoat DH, Glab A, Hadjiconstantinou M, Mensa J, Northern A, Davies MJ. A model based cost-utility analysis of embedding referral to structured self-management education into standard practice (Embedding) compared to usual care for people with type 2 diabetes diagnosis in the last 12 months in England. BMJ Open. 2025 Jan 21. https://doi.org/10.1136/bmjopen-2024-093327

References

1. Davies MJ, Bodicoat DH, Brennan A, Dixon S, Eborall H, Glab A, Gray LJ, Hadjiconstantinou M, Huddlestone L, Hudson N, Keetharuth A. Uptake of self-management education programmes for people with type 2 diabetes in primary care through the embedding package: a cluster randomised control trial and ethnographic study. BMC Primary Care. 2024 Apr 25;25(1):136.
2. Davies MJ, Kristunas CA, Alshreef A, Dixon S, Eborall H, Glab A, Huddlestone L, Hudson N, Khunti K, Martin G, Northern A. The impact of an intervention to increase uptake to structured self-management education for people with type 2 diabetes mellitus in primary care (the embedding package), compared to usual care, on glycaemic control: study protocol for a mixed methods study incorporating a wait-list cluster randomised controlled trial. BMC Family Practice. 2019 Dec;20:1-5.
3. Davies MJ, Agarwal S, Bodicoat D, Brennan A, Dixon S, Eborall H, Glab A, Gray LJ, Hadjiconstantinou M, Huddlestone L, Hudson N, Keetharuth A, Khunti K, Kristunas C, Martin G, Northern A, Patterson M, Pollard D, Pritchard R, Schreder S, Speight J, Stribling B, Sturt J, Turner J, Weis C. Increasing uptake of self-management education programmes for type 2 diabetes in primary care: the Embedding research programme including an RCT. Programme Grants for Applied Research. In Press
4. Pollard D, Keetharuth A, Brennan A, Bodicoat DH, Glab A, Hadjiconstantinou M, Mensa J, Northern A, Davies MJ. A model based cost-utility analysis of embedding referral to structured self-management education into standard practice (Embedding) compared to usual care for people with type 2 diabetes diagnosis in the last 12 months in England. BMJ Open. 2025 Jan 21.