Data for the paper: "Optimization of the failure criterion in micro-Finite Element models of the mouse tibia for the non-invasive prediction of its failure load in preclinical applications"

<div>Data used in the paper: "Optimization of the failure criterion in micro-Finite Element models of the mouse tibia for the non-invasive prediction of its failure load in preclinical applications"<div>Oliviero, Owen, Reilly, Bellantuono, Dall'Ara<br></div><div>published in JMBBM<br></div><div><br></div><div>We share here an example of ex vivo microCT image used for the assessment, and the results obtained from the different analyses.</div><div><br></div><div>Short description of the files included:</div><div><p><br></p><p>Densitometric_and_morphometric_parameters.xlsx includes:</p><p>-Densitometric parameters, and correlations with experimental mechanical data, calculated for each specimen and each region of interest</p><p>Total = total volume of interest (80% of tibia length)</p><p>10 Longitudinal sections: section 1 corresponds to proximal tibia, section 10 corresponds to distal tibia</p><p>Sectors: anterior (A), posterior (P), medial (M) and lateral (L)</p><p><br></p><p>-Morphometric parameters calculated for each specimen, and correlations with experimental mechanical data.</p><p></p><p> </p><p>-microFE_results.xlsx includes:</p><p>Stiffness estimated for each specimen with microFE models, and correlations with experimental data.</p><p>Failure load estimated with microFE models, and correlations with experimental data, for each failure criterion:</p><p>Pistoia method</p><p>Compression: tibia fails when a portion of the nodes (failure volume) reaches a critical compressive (third principal) strain level</p><p>Tension: tibia fails when a portion of the nodes reaches a critical tensile (first principal) strain level</p><p>Compression&Tension: tibia fails when a portion of the nodes reaches a critical strain, either in tension or in compression</p><p>Sections: tibia fails when the median first principal strain or third principal strain in one section (tibia divided into ten portions) or in one sector (tibia divided into ten sections and each section divided into anterior and posterior partitions; 20 portions in total) reaches a critical strain level</p><p></p><p> </p><p>-microCT data:</p><p>Example of a segmented microCT image used as input for the microFE model (Specimen1, C57BL/6J, wild type, 16 weeks of age, right tibia).</p><p></p></div><div><br></div><div><br></div><div>In case the reader is interested in the whole database they should contact Dr Enrico Dall'Ara (e.dallara@sheffield.ac.uk).</div></div><div><div><div><div><h4></h4></div></div><div><a href="https://doi.org/10.1016/j.actbio.2020.09.011" rel="noopener noreferrer noopener noreferrer" target="_blank"></a></div></div><div><a href="https://figshare.shef.ac.uk/" rel="noopener noreferrer noopener noreferrer" target="_blank"></a></div><div><h3></h3><ul><li><a href="https://figshare.shef.ac.uk/search?q=:category: " rel="noopener noreferrer"></a></li></ul></div><div><h3></h3><div><a href="https://figshare.shef.ac.uk/search?q=:keyword: "></a><a href="https://figshare.shef.ac.uk/search?q=:keyword: "></a><a href="https://figshare.shef.ac.uk/search?q=:keyword: "></a><a href="https://figshare.shef.ac.uk/search?q=:keyword: "></a><a href="https://figshare.shef.ac.uk/search?q=:keyword: "></a></div></div></div><div></div>