Electrospun Fibres of Polyhydroxyalkanoate/Bacterial Cellulose blends and their role in Nerve Tissue Engineering
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posted on 2025-01-23, 16:34 authored by Emmanuel Asare, Bahareh Azimi, Elona Vasili, David
A. Gregory, Mahendra RautMahendra Raut, Caroline Taylor, Stefano Linari, Serena Danti, Ipsita RoyIpsita RoyThis study involved the development of novel blend electrospun nanofibres through the combination of short-chain length polyhydroxyalkanoates (SCL-PHAs), medium-chain length polyhydroxyalkanoates (MCL-PHAs), and bacterial cellulose (BC) using the electrospinning technique. The resultant fibrous materials were characterised for their thermal properties, morphology, and cytocompatibility with NG108-15 neuronal cells. The incorporation of BC into the blend significantly enhanced the thermal stability of the polymer matrix, as evidenced by thermogravimetric analysis.
Funding
This project has been supported by the European Union’s Horizon 2020 research and innovation programme H2020-MSCA-RISE under grant agreement No. 777926, as well as by ECOFUNCO (Grant Agreement No. 837863) and several grants from the Engineering and Physical Sciences Research Council (EPSRC), specifically EP/X026108/1, EP/V012126/1, and EP/X024040/1.
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