Electrospun Fibres of Polyhydroxyalkanoate/Bacterial Cellulose blends and their role in Nerve Tissue Engineering
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posted on 2025-01-23, 16:34 authored by Emmanuel AsareEmmanuel Asare, Bahareh Azimi, Elona Vasili, David
A. Gregory, Mahendra RautMahendra Raut, Caroline TaylorCaroline Taylor, Stefano Linari, Serena Danti, Ipsita RoyIpsita Roy<p dir="ltr">This study involved the development of novel blend electrospun nanofibres through the combination of short-chain length polyhydroxyalkanoates (SCL-PHAs), medium-chain length polyhydroxyalkanoates (MCL-PHAs), and bacterial cellulose (BC) using the electrospinning technique. The resultant fibrous materials were characterised for their thermal properties, morphology, and cytocompatibility with NG108-15 neuronal cells. The incorporation of BC into the blend significantly enhanced the thermal stability of the polymer matrix, as evidenced by thermogravimetric analysis.</p>
Funding
This project has been supported by the European Union’s Horizon 2020 research and innovation programme H2020-MSCA-RISE under grant agreement No. 777926, as well as by ECOFUNCO (Grant Agreement No. 837863) and several grants from the Engineering and Physical Sciences Research Council (EPSRC), specifically EP/X026108/1, EP/V012126/1, and EP/X024040/1.
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