Human amyotrophic lateral sclerosis/motor neuron disease: The disease-associated microglial pathway is upregulated. nCounter files for spinal cord and motor cortex
dataset
posted on 2024-11-26, 15:16 authored by Bridget AshfordBridget Ashford, Julie Simpson, Charlotte Dawson, Delphine Boche, Johnathan Cooper-KnockJohnathan Cooper-Knock, Paul HeathPaul Heath, Daniel FillinghamDaniel Fillingham, Charlie Appleby-Mallinder, Wenbin Wei, Mark DunningMark Dunning, John HighleyJohn HighleyBruker Spatial Biology (previously NanoString) Sprint Profiler Gene expression assay using the nCounter® Human Neuroinflammation Panel (XT-CSO-HNROI1-12) to assess gene expression in post mortem frozen tissue from motor cortex from neurologically healthy controls and individuals with ALS/MND.
The Sheffield Brain Tissue Bank (SBTB) which provided the tissue used here has ethical permission to function as a Research Tissue Bank. At the time the work was undertaken, this was covered by a favourable opinion from the Scotland A Research Ethics Committee (Reference 19/SS/0029). SBTB adheres to consenting protocols laid down by the UK Human Tissue Authority and agreed by Research Ethics Committee. This project is thus covered by SBTB ethics.
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