Schematic representation of cell population in discrete models, where cells
are represented in pink with nucleus in red. (A) On-lattice approach: squared
2D lattice where each lattice element contains one single cell. At the top
right void locations are free to be occupied by daughter cells. (B) Cellular
Potts model: squared lattice where each cell occupies several lattice elements.
Cells are represented with different colors. (C) Compartmental model 2D:
similar to squared lattice but having several cells per lattice element. (D)
Off-lattice agent based approach in 3D: cells are represented by spheres and
are not constrained in a lattice. (E) Off-lattice Vertex based 2D: cell surface
delimited by polyhedral vertices of a Voronoi tessellation.<div><em>The figure is generated using Inkscape open source program (www.inkscape.org)</em></div>
Funding
“Accelerating in silico cancer research with graphic processors” of the Engineering and Physical Science Research Council, EPSRC grant code R/141365-11-1