A Framework for the Economic Evaluation of Sequential Therapies for Chronic Conditions (2014)

<div> Background:</div><div>Cost-effectiveness models often evaluate a sequence of treatments </div><div>Downstream implications of a sequence should be captured Compare sequences within standard economic evaluation framework </div><div><br></div><div>Problem:</div><div> For conditions such as rheumatoid arthritis, an optimal treatment sequence has not been identified[1] </div><div> Large number of sequences requires excessively large computational time (estimate cost and QALYs estimated for every sequence) </div><div>Computation time increases when using individual patient simulation </div><div>Evidence for a fully sequential model is not likely to be available <br>Model <br></div>