Current position of response adaptive randomisation in research practice: Uptake, gaps, and lessons for the future.
poster
posted on 2025-04-08, 14:46 authored by Isabelle WilsonIsabelle Wilson, Munyaradzi DimairoMunyaradzi Dimairo, Steven JuliousSteven Julious, Christina YapChristina Yap, Sue ToddAccepted poster presentation for the International Clinical Trials Methodology Conference (ICTMC) 2024, at the Edinburgh International Conference Centre.
Adaptive designs (ADs) offer clinical trials flexibility to modify design aspects based on accumulating interim outcome data. Response adaptive randomisation (RAR) adjusts treatment allocation based on interim outcome data to favour promising treatments. Despite scientific appeal, RAR adoption lags behind other ADs. An understanding of RAR methods and their application in real trials could provide insights and practical resources, as well as highlighting gaps.
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NIHR302738
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