<div>The Craggs Lab in the Department of Chemistry have developed a fully open-source instrument for Single-molecule Förster Resonance Energy Transfer (smFRET) measurements, a powerful technique with applications spanning many disciplines across biophysics, biology and biomedicine.</div><div><br></div><div>This case study describes their approach to open research, how they have made smFRET more accessible and the benefits of this.</div><div><br></div><div>This case study won the inaugural Open Research Prize at the University of Sheffield in 2021.</div>