This contains statistical simulation reports for proposed trials to address the research questions within the proposed TipTop platform. It describes the statistical methods used and the results relating to each research question.
Statistical simulation report for the respiratory research question within the TipTop platform: sample size and operating characteristics for an adaptive design.
Tiptop statistical simulation report for the cord clamping research question: sample size calculation and operating characteristics of an adaptive design.
Funding
Accelerating the development of a perinatal platform trial to efficiently evaluate the effectiveness of multiple interventions in maternity and neonatal care
NIHR Evaluation Trials and Studies Coordinating Centre