<p>The main document is a Word file named UmbrellaReviewProtocol.docx, which is a document containing a protocol for an Umbrella Review. The title of the protocol is: Issues, challenges and opportunities for economic evaluation of orphan drugs: an umbrella review protocol</p>
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<p>The other Word files contain supplementary materials associated with the umbrella review protocol. For example, in the procotol these files are referenced as "additional file 1". The following files are included: additional files 1.docx, additional files 2.docx, and additional files 3.docx. </p>
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<p>The files will be referenced by the Umbrella Review which is to be submitted for peer-review. </p>
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