The cost-effectiveness of providing DAFNE to subgroups of predicted responders 2012
poster
posted on 2020-02-27, 00:07 authored by J Kruger, A Brennan, S Heller<p>The Dose Adjustment for Normal Eating (DAFNE) course is a
structured education programme for adult patients with Type 1 diabetes. DAFNE has been found to improve glycosylated
haemoglobin (HbA1c) levels in UK Type 1 diabetes patients1 and a
cost-effectiveness modelling analysis concluded that DAFNE was cost-effective
from the NHS perspective2. This analysis
assumed that HbA1c benefit experienced by patients receiving DAFNE was
homogeneous, however it has been found that HbA1c response to DAFNE is highly
variable between patients. Although some patients do experience significant
HbA1c reductions after DAFNE, other patients experience a worsening of HbA1c1,3
and some find it difficult to maintain initial HbA1c improvements4. Targeting DAFNE to only those patients that
are expected to benefit may improve the cost-effectiveness of the intervention.</p>
<p> </p>
<p>This study aims to explore statistical modelling
methodologies to predict individual clinical responses to DAFNE from
psychosocial characteristics and incorporate psychosocial predictors into an
economic simulation model to investigate the cost-effectiveness of providing
DAFNE to subgroups of predicted responders.</p>
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